DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Stress, epigenetics and depression: a systematic review

C Park, JD Rosenblat, E Brietzke, Z Pan, Y Lee… - Neuroscience & …, 2019 - Elsevier
Environmental stressors, such as childhood maltreatment, have been recognized to
contribute to the development of depression. Growing evidence suggests that epigenetic …

[HTML][HTML] Genetics factors in major depression disease

M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

[HTML][HTML] Childhood trauma in schizophrenia: current findings and research perspectives

D Popovic, A Schmitt, L Kaurani, F Senner… - Frontiers in …, 2019 - frontiersin.org
Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …

Is subthreshold depression in adolescence clinically relevant?

BK Noyes, DP Munoz, S Khalid-Khan, E Brietzke… - Journal of affective …, 2022 - Elsevier
Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …

Brain‐derived neurotrophic factor and post‐stroke depression

E Zhang, P Liao - Journal of neuroscience research, 2020 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its
role in mood disorders, including post stroke depression (PSD), is also recognized with …

Could epigenetics help explain racial disparities in chronic pain?

EN Aroke, PV Joseph, A Roy, DS Overstreet… - Journal of pain …, 2019 - Taylor & Francis
African Americans disproportionately suffer more severe and debilitating morbidity from
chronic pain than do non-Hispanic Whites. These differences may arise from differential …

What do DNA methylation studies tell us about depression? A systematic review

M Li, C D'Arcy, X Li, T Zhang, R Joober… - Translational psychiatry, 2019 - nature.com
There has been a limited number of systematic reviews conducted to summarize the
overview of the relationship between DNA methylation and depression, and to critically …

The efficacy of S-adenosyl methionine and probiotic supplementation on depression: a synergistic approach

H Ullah, A Khan, KRR Rengasamy, A Di Minno… - Nutrients, 2022 - mdpi.com
Depression is a common and serious health issue affecting around 280 million people
around the world. Suicidal ideation more frequently occurs in people with moderate to …