Although the last decade has seen tremendous progress in drugs that treat cystic fibrosis
(CF) due to mutations that lead to protein misfolding, there are approximately 8-10% of …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) has killed hundreds of thousands of humans in a global …

Inhibition of BTK has emerged as a promising therapeutic approach to target the CNS-
compartmentalized inflammation. Results from phase 3 clinical trials will shed light on …

Background Recently, concern has been raised about the influence of the previous disease-
modifying treatments (DMTs) on the clinical efficacy of ocrelizumab (OCR). We aimed to …

Objective Repeated intravenous administration of anti‐CD20 depleting monoclonal
antibodies 6 months apart is among the highly effective treatment options in multiple …

The first formal consensus diagnostic criteria for myelin oligodendrocyte glycoprotein
antibody-associated disease (MOGAD) were recently proposed. Yet, the distinction of …

Theiler's murine encephalomyelitis virus (TMEV) infected mice have been often used as an
animal model for Multiple sclerosis (MS) due to their similar pathology in the central nervous …

Successful therapy with anti-CD20 monoclonal antibodies (mAbs) has reinforced the key
role of B cells in the immunopathology of multiple sclerosis (MS). This study aimed to …

Background Recent evidence has shown dopamine as a major regulator of inflammation.
Accordingly, dopaminergic regulation of immune cells plays an important role in the …

The first description of neuromyelitis optica by Eugène Devic and Fernand Gault dates back
to the 19th century, but only the discovery of aquaporin-4 autoantibodies in a major subset of …