One reason for a lack of response to rituximab as well as infusion-related anaphylactic
adverse events is the development of antidrug Abs to rituximab. Besides rituximab, a …

ABSTRACT Interleukin 4 (IL4)-induced gene 1 (IL4I1) is an oxidase that degrades l-
phenylalanine into phenylpyruvate, hydrogen peroxide, and ammonia. In contrast to other …

Background At present, anti-CD20 monoclonal antibody treatments targeting systemic lupus
erythematosus (SLE) are complex, variable, and often have disappointing outcomes. High …

Objectives To report CD19+ B-cell counts and possible adverse effects on infants of mothers
exposed to anti-CD20 mAbs≤ 6 months before/during pregnancy or lactation. Methods We …

Purpose. Decreased expression of TLR homolog CD180 in peripheral blood B cells and its
potential role in antibody production have been described in autoimmune diseases …

B cells play a major role in the pathogenesis of many autoimmune diseases like MS,
rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti‐CD20 …

Rituximab (RTX) for immune-mediated inflammatory disease (IMID) with interstitial
pneumonitis (IP) results in non-response in about a third of patients for reasons not well …

The fluid compartment surrounding the central nervous system (CNS) is a unique source of
immune cells capable of reflecting the pathophysiology of neurologic diseases. While …

Background Previous studies have shown an effect of tonsillectomy and greater risk for
future autoimmune diseases. Currently there are only few outdated analyses of tonsillectomy …

A clear understanding of the origin and role of the different subtypes of the B cell lineage
involved in the activity or remission of multiple sclerosis (MS) is important for the treatment …