Treating MS has been difficult. One successful drug is Ocrelizumab (anti-CD20), used for the
chronic relapsing MS (RMS) and the progressive MS (PMS) forms. TH40 cells are …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …

Neurodegeneration in inflammatory conditions in the central nervous system follows a basic
pathway, mediated by pro-inflammatory cytokines and macrophage and microglia activation …

Abstract Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in
multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was …

Рассеянный склероз (РС)-хроническое демиелинизирующее заболевание
центральной нервной системы с аутоиммунным механизмом развития. Долгое время …

Objectives. Immune reconstitution therapies (IRT), which include antibody-based cell-
depleting therapies targeting CD52+(alemtuzumab) or CD20+(rituximab, ocrelizumab) …

Background and Objectives Antibodies to CD20 efficiently reduce new relapses in multiple
sclerosis (MS), and ocrelizumab has been shown to be effective also in primary progressive …

Abstract (DE) Multiple Sklerose (MS) ist eine chronisch-entzündliche Erkrankung des
Zentralen Nervensystems. Die Bedeutung der B-Zellen bei der MS-Pathogenese ist in den …

Abstract αCD20 B cell-depleting antibody (αCD20) therapy has become a first-line treatment
for multiple sclerosis (MS), and while the mechanism for this efficacy is incompletely …

AIM: Autologous hematopoietic stem cell transplant (AHSCT) has proven to be an effective
treatment for aggressive multiple sclerosis (MS). It is associated with significant risks and an …