Translational Aspects of Immunotherapeutic Targets in Multiple Sclerosis

V Fleischer - Translational Methods for Multiple Sclerosis Research, 2021 - Springer
In this chapter, selected immunopharmacological targets that are currently part of multiple
sclerosis (MS) therapy are described, with particular attention paid to translational aspects in …

Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity

Y Tesfagiorgis, EA Kemal, HC Craig, KA Parham… - Journal of …, 2024 - Elsevier
Anti-CD20 B cell depleting therapies have demonstrated that B cells are important drivers of
disease progress in Multiple Sclerosis, although the pathogenic mechanisms are not well …

Preclinical development of ACT-1004-1239, a potent and selective CXCR7/ACKR3 antagonist in multiple sclerosis treatment

L Pouzol - 2022 - theses.hal.science
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
involving inflammation, demyelination, and axonal degeneration. Remarkable advances …

Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion

Y Tesfagiorgis - 2021 - search.proquest.com
B cell depleting therapies have been effective in the treatment of Multiple Sclerosis (MS), yet
to date little is known about how B cells promote disease pathogenesis. B cells can be found …

Characterising the Role of B cells in Gastric Cancer

LM Pang - 2022 - opal.latrobe.edu.au
Characterising the Role of B cells in Gastric Cancer Page 1 Characterising the Role of B cells
in Gastric Cancer Lokman Pang Bachelor of Science (with Honours) Submitted in Total …

Descubrimiento de nuevas terapias y técnicas de diagnóstico no invasivas en esclerosis múltiple

R Benítez Fernández - 2021 - digital.csic.es
Los oligodendrocitos son las células gliales encargadas de la mielinización de los axones y
desempeñan un papel fundamental en el desarrollo y la correcta transmisión de los …

Mechanism of regulatory B cells during relapse and remission in multiple sclerosis and neuromyelitis optica spectrum disorder patients

김예슬 - 2022 - ir.ymlib.yonsei.ac.kr
Currently, human Bregs have been identified at different stages of B cell development and
consist of various B cell surface markers; these include CD19+CD24hiCD38hi immature …

[PDF][PDF] Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis

N Nissimov - 2021 - ediss.uni-goettingen.de
Multiple sclerosis (MS, disseminate encephalomyelitis, ICD-10: G35) is a chronic primarily
inflammatory disease of the central nervous system (CNS) in which myelin and axons are …

B Cell Responses in an Animal Model of Neuroinflammation: Implications for Multiple Sclerosis

DSW Lee - 2021 - search.proquest.com
Multiple sclerosis is a complex disease with no definitive cause or cure. Positive clinical
trials such as those with anti-CD20 and negative clinical trials such as those with TACI-Ig–all …

[PDF][PDF] POSSIBILITIES OF THE FLOW CYTOMETRY FOR THE DETECTION OF B-LYMPHOCYTES IN PATIENTS WITH MULTIPLE SCLEROSIS AFTER THE USE OF …

CY Yuryevna - UAE–RUSSIA–INDIA, 2022 - ran-nauka.ru
The article presents the results of the analysis of the parameters of adaptive cellular
immunity, in particular, the immunophenotypic features of peripheral blood B-lymphocytes in …