Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading
researchers to reflect on the key challenges and opportunities faced by the field of genetics …

We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries)
may facilitate our efforts towards further improvement. Here, we report the deep …

Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting
from constitutive pigmentation variability. This paper will review the characterization of skin …

Abstract Forensic DNA Phenotyping (FDP), ie the prediction of human externally visible traits
from DNA, has become a fast growing subfield within forensic genetics due to the …

Therapeutic options for autoimmune diseases typically consist of broad and targeted
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …

We report a genome-wide association scan in> 6,000 Latin Americans for pigmentation of
skin and eyes. We found eighteen signals of association at twelve genomic regions. These …