Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Human induced pluripotent stem cells (hiPSCs,,) are useful in disease modeling and drug
discovery, and they promise to provide a new generation of cell-based therapeutics. To date …

The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use
patient-specific somatic cells, which are a valuable source for disease modeling and drug …

After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been
made to develop more efficient methods for generating iPSCs without foreign gene …

Forced expression of selected transcription factors can transform somatic cells into
embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is …

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …

Since the first discovery that human pluripotent stem cells (hPS cells) can differentiate to
cardiomyocytes, efforts have been made to optimize the conditions under which this process …

A mutation in the centrosomal‐P4. 1‐associated protein (CPAP) causes Seckel syndrome
with microcephaly, which is suggested to arise from a decline in neural progenitor cells …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features,
including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA …