The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Dementia prevention research has progressed rapidly in recent years, with publication of
several large lifestyle intervention trials, and renewed interest in pharmacological …

'Covert'cerebral small vessel disease (ccSVD) is common on neuroimaging in persons
without overt neurological manifestations, and increases the risk of future stroke, cognitive …

White matter deterioration is associated with cognitive impairment in healthy aging and
Alzheimer's disease. It is critical to identify interventions that can slow down white matter …

Hippocampal volume is a marker of brain health and is reduced with aging and neurological
disease. Exercise may be effective at increasing and preserving hippocampal volume …

Smith and Markus Cerebral Small Vessel Disease Trials 39 dysmetabolism, and glucose
dysregulation that are the primary targets for current ischemic stroke prevention. As an …

A growing body of evidence clearly indicates the beneficial effects of physical activity (PA)
on cognition. The importance of PA is now being reevaluated due to the increase in …

Vascular contributions to cognitive impairment and dementia, specifically cerebral small
vessel disease (CSVD), are the second most common cause of dementia. Currently, there …

5. Dwyer-Lindgren L, Bertozzi-Villa A, Stubbs RW, Morozoff C, Mackenbach JP, van Lenthe
FJ, et al. Inequalities in life expectancy among us counties, 1980 to 2014: temporal trends …

Alzheimer's disease (AD) is the main neurodegenerative disorder characterized by several
pathophysiological features, including the misfolding of the tau protein and the amyloid beta …