Gardenia (Gardenia jasminoides Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and …

C Jin, AWS Zongo, H Du, Y Lu, N Yu, X Nie… - Critical Reviews in …, 2023 - Taylor & Francis
Gardenia fruit (GF) is the mature fruit of Gardenia jasminoides Ellis, boasting a rich array of
nutrients and phytochemicals. Over time, GF has been extensively utilized in both food and …

A comprehensive review of ethnopharmacology, chemical constituents, pharmacological effects, pharmacokinetics, toxicology, and quality control of gardeniae fructus

L Wang, S Chen, S Liu, AM Biu, Y Han, X Jin… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Gardeniae Fructus (GF), the desiccative mature
fruitage of Gardenia jasminoides J. Ellis (G. jasminoides), belongs to the Rubiaceae family. It …

Canna x generalis LH Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress …

TN Mahmoud, WH El-Maadawy, ZA Kandil… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Genus Canna is used in folk medicine as
demulcent, diaphoretic, antipyretic, mild laxative and in gastrointestinal upsets therapy …

Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway

Y Deng, X Chu, Q Li, G Zhu, J Hu, J Sun, H Zeng… - Phytomedicine, 2024 - Elsevier
Background As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis
plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated …

Kaempferol from Penthorum chinense Pursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced …

YC Du, L Lai, H Zhang, FR Zhong, HL Cheng… - Food & function, 2020 - pubs.rsc.org
Acetaminophen (APAP) is one of the safest and most effective over-the-counter (OTC)
analgesics and antipyretics, but excessive doses of APAP will induce hepatotoxicity with …

[HTML][HTML] Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes

X Wang, J Rao, Z Tan, T Xun, J Zhao… - Frontiers in …, 2022 - frontiersin.org
Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to
drug detoxification, cell metabolism, and homeostasis. CYP450s belonging to CYP families …

[HTML][HTML] Effect of vitexin on alleviating liver inflammation in a dextran sulfate sodium (DSS)-induced colitis model

S Duan, X Du, S Chen, J Liang, S Huang, S Hou… - Biomedicine & …, 2020 - Elsevier
As one of commonly used herbs with dual-purpose of drug and food, it has been reported
that vitexin has hepatoprotective effects. However, the protective effects of vitexin on colitis …

[HTML][HTML] Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal

GA Mohamed Kamel, E Harahsheh… - Molecular Biology Reports, 2022 - Springer
Background Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic
medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID …

Geniposide alleviates oxidative damage in hepatocytes through regulating miR-27b-3p/nrf2 Axis

J Li, H Ge, Y Xu, J Xie, F Yan… - Journal of Agricultural and …, 2022 - ACS Publications
Geniposide (GEN), a main compound extracted from Gardenia jasminoides fruit, has various
biological activities including anti-inflammation, cellular damage alleviation …

The complex roles of neutrophils in APAP‐induced liver injury

H Guo, S Chen, M Xie, C Zhou, M Zheng - Cell Proliferation, 2021 - Wiley Online Library
Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which
is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the …