Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …
children. Approximately 36% of episodes of status epilepticus do not respond to the current …
New GABA-targeting therapies for the treatment of seizures and epilepsy: II. Treatments in clinical development
E Perucca, HS White, M Bialer - CNS drugs, 2023 - Springer
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …
Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus
Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of
cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An …
cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An …
Dogs as a natural animal model of epilepsy
W Löscher - Frontiers in veterinary science, 2022 - frontiersin.org
Epilepsy is a common neurological disease in both humans and domestic dogs, making
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …
Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development
SN Kurki, P Uvarov, AS Pospelov, K Trontti… - Cerebral …, 2023 - academic.oup.com
Abstract The Na-K-2Cl cotransporter NKCC1 is widely expressed in cells within and outside
the brain. However, our understanding of its roles in brain functions throughout …
the brain. However, our understanding of its roles in brain functions throughout …
Fundamental Neurochemistry Review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy
Epilepsy is a common neurological disorder associated with alterations of excitation‐
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
[HTML][HTML] GABAergic circuits drive focal seizures
E Dossi, G Huberfeld - Neurobiology of Disease, 2023 - Elsevier
Epilepsy is based on abnormal neuronal activities that have historically been suggested to
arise from an excess of excitation and a defect of inhibition, or in other words from an …
arise from an excess of excitation and a defect of inhibition, or in other words from an …
Astrocytic NKCC1 inhibits seizures by buffering Cl− and antagonizing neuronal NKCC1 at GABAergic synapses
TD Nguyen, M Ishibashi, AS Sinha, M Watanabe… - …, 2023 - Wiley Online Library
Objective A pathological excitatory action of the major inhibitory neurotransmitter γ‐
aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl− importer NKCC1 …
aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl− importer NKCC1 …
[HTML][HTML] Mechanisms of cerebrospinal fluid and brain interstitial fluid production
J Xiang, Y Hua, G Xi, RF Keep - Neurobiology of disease, 2023 - Elsevier
Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus
both being major neurological conditions. Fluid movement from blood into brain is one …
both being major neurological conditions. Fluid movement from blood into brain is one …
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease
B Boyarko, S Podvin, B Greenberg… - Frontiers in …, 2023 - frontiersin.org
Therapeutics discovery and development for Alzheimer's disease (AD) has been an area of
intense research to alleviate memory loss and the underlying pathogenic processes. Recent …
intense research to alleviate memory loss and the underlying pathogenic processes. Recent …