Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Simple Summary Grimace scales for laboratory animals were first reported ten years ago.
Yet, despite their promise as pain assessment tools it appears that they have not been …

Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia,
dental pain, and debilitating headaches, affects millions of Americans each year with …

The oral cavity is a portal into the digestive system, which exhibits unique sensory
properties. Like facial skin, the oral mucosa needs to be exquisitely sensitive and selective …

Simple Summary The Mouse Grimace Scale (MGS) was developed as a tool for the
measurement of pain in laboratory mice. There have been a number of studies focused on …

Orthodontic treatment in older adults is more difficult than in younger adults, partially due to
delayed osteogenesis caused by senescence of human periodontal ligament stem cells …

Objectives Orthodontic mechanical force on the periodontal ligament induces extracellular
adenosine triphosphate (ATP) release. However, mechanosensitive molecules have not …

Teeth are subject to a variety of mechanical forces and vectors. The periodontal ligament
(PDL), fibrous tissue that connects the cementum of the tooth to the bony socket, plays a …

Trigeminal neurons convey somatosensory information from craniofacial tissues. In mouse
brain, ascending projections from medullary trigeminal neurons arrive at taste neurons in the …

Periodontitis is one of the most common oral diseases in humans, affecting over 40% of
adult Americans. Pain-sensing nerves, or nociceptors, sense local environmental changes …