Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung

C Darquenne, JS Fleming, I Katz, AR Martin… - Journal of aerosol …, 2016 - liebertpub.com
Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …

Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics

A Artzy-Schnirman, SA Raviv, OD Flikshtain… - Advanced drug delivery …, 2021 - Elsevier
Over the past years, advanced in vitro pulmonary platforms have witnessed exciting
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …

Aerosol therapy during noninvasive ventilation or high-flow nasal cannula

DR Hess - Respiratory care, 2015 - rc.rcjournal.com
Noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC) are increasingly used for
patients with acute respiratory failure. Some patients receiving these therapies might also …

[HTML][HTML] Contemporary formulation development for inhaled pharmaceuticals

T Sou, CAS Bergström - Journal of Pharmaceutical Sciences, 2021 - Elsevier
Pulmonary delivery has gained increased interests over the past few decades. For
conditions within the respiratory tract, targeted drug delivery directly to the site of action can …

[图书][B] Microfluidics: fundamentals, devices, and applications

Y Song, D Cheng, L Zhao - 2018 - books.google.com
The first book offering a global overview of fundamental microfluidics and the wide range of
possible applications, for example, in chemistry, biology, and biomedical science. As such, it …

[HTML][HTML] Can 'extrafine'dry powder aerosols improve lung deposition?

AH De Boer, D Gjaltema, P Hagedoorn… - European Journal of …, 2015 - Elsevier
There is increasing interest in the use of so-called 'extrafine'aerosols to target the small
airways in the management of asthma and COPD. Using previously presented deposition …

Validating whole-airway CFD predictions of DPI aerosol deposition at multiple flow rates

PW Longest, G Tian… - Journal of aerosol …, 2016 - liebertpub.com
Background: The objective of this study was to compare aerosol deposition predictions of a
new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) …

Devices for improved delivery of nebulized pharmaceutical aerosols to the lungs

W Longest, B Spence, M Hindle - Journal of aerosol medicine and …, 2019 - liebertpub.com
Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …

High dose dry powder inhalers to overcome the challenges of tuberculosis treatment

MAM Momin, IG Tucker, SC Das - International journal of pharmaceutics, 2018 - Elsevier
Tuberculosis (TB) is a major global health burden. The emergence of the human
immunodeficiency virus (HIV) epidemic and drug resistance has complicated global TB …

Formulation techniques for high dose dry powders

AD Brunaugh, HDC Smyth - International journal of pharmaceutics, 2018 - Elsevier
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the
treatment of both local pulmonary conditions and systemic diseases. Though DPIs are …