Recent Developments in Aerosol Pulmonary Drug Delivery: New Technologies, New Cargos, and New Targets
IR Woodward, CA Fromen - Annual Review of Biomedical …, 2024 - annualreviews.org
There is nothing like a global pandemic to motivate the need for improved respiratory
treatments and mucosal vaccines. Stimulated by the COVID-19 pandemic, pulmonary …
treatments and mucosal vaccines. Stimulated by the COVID-19 pandemic, pulmonary …
[HTML][HTML] Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes
Inhalation aerosols represent a cornerstone in treating pediatric respiratory conditions and
may be administered as soon as following birth in preterm neonates or shortly after in …
may be administered as soon as following birth in preterm neonates or shortly after in …
CFD guided optimization of nose-to-lung aerosol delivery in adults: effects of inhalation waveforms and synchronized aerosol delivery
Purpose The objective of this study was to optimize nose-to-lung aerosol delivery in an adult
upper airway model using computational fluid dynamics (CFD) simulations in order to guide …
upper airway model using computational fluid dynamics (CFD) simulations in order to guide …
Computational fluid dynamics (CFD) simulations of spray drying: linking drying parameters with experimental aerosolization performance
Purpose The purpose of this study was to develop a new computational fluid dynamics
(CFD)-based model of the complex transport and droplet drying kinetics within a laboratory …
(CFD)-based model of the complex transport and droplet drying kinetics within a laboratory …
Combining experimental and computational techniques to understand and improve dry powder inhalers
ABSTRACT Introduction Dry Powder Inhalers (DPIs) continue to be developed to deliver an
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …
Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery
Tenacious sputum poses a critical diffusion barrier for aerosol antibiotics used to treat cystic
fibrosis (CF) lung infection. We conducted a proof-of-concept study using dense poly …
fibrosis (CF) lung infection. We conducted a proof-of-concept study using dense poly …
Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations
Spray drying can be utilized to produce highly dispersible powder aerosol formulations.
However, these formulations are known to be hygroscopic, leading to potential solid-state …
However, these formulations are known to be hygroscopic, leading to potential solid-state …
Development of a high efficiency dry powder inhaler: effects of capsule chamber design and inhaler surface modifications
Purpose The objective of this study was to explore the performance of a high efficiency dry
powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based …
powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based …
Characterization of a new high-dose dry powder inhaler (DPI) based on a fluidized bed design
The objective of this study was to develop a new high-efficiency dry powder inhaler (DPI)
that can effectively aerosolize large masses (25–100 mg) of spray dried powder …
that can effectively aerosolize large masses (25–100 mg) of spray dried powder …
Efficient nose-to-lung (N2L) aerosol delivery with a dry powder inhaler
Purpose: Delivering aerosols to the lungs through the nasal route has a number of
advantages, but its use has been limited by high depositional loss in the extrathoracic …
advantages, but its use has been limited by high depositional loss in the extrathoracic …