Mechanism and applications of CRISPR/Cas-9-mediated genome editing
M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
[HTML][HTML] Advances in CRISPR therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges
M Asmamaw Mengstie - Frontiers in Bioengineering and …, 2022 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …
Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
J O'Keeffe Ahern, I Lara-Sáez, D Zhou, R Murillas… - Gene therapy, 2022 - nature.com
Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an
efficient and safe delivery system into cells and tissues continues to hinder clinical …
efficient and safe delivery system into cells and tissues continues to hinder clinical …
[HTML][HTML] Cas13d: a new molecular scissor for transcriptome engineering
The discovery of Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and its
associated Cas endonucleases in bacterial and archaeal species allowed scientists to …
associated Cas endonucleases in bacterial and archaeal species allowed scientists to …
Therapeutic promise of engineered nonsense suppressor tRNAs
Nonsense mutations change an amino acid codon to a premature termination codon (PTC)
generally through a single‐nucleotide substitution. The generation of a PTC results in a …
generally through a single‐nucleotide substitution. The generation of a PTC results in a …
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome
editing system has been a major technological breakthrough that has brought revolutionary …
editing system has been a major technological breakthrough that has brought revolutionary …
[HTML][HTML] Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Gene therapy is a flourishing field with the potential to revolutionize the treatment of genetic
diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient …
diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient …
Role of CRISPR/Cas9 in the treatment of Duchenne muscular dystrophy and its delivery strategies
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder brought on by mutations
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …