Cellulose is a widespread component of bacterial biofilms, where its properties of
exceptional water retention, high tensile strength, and stiffness prevent dehydration and …

In biological systems, large and complex structures are often assembled from multiple
simpler identical subunits. This strategy—homooligomerization—allows efficient genetic …

Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host
cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT …

The architecture of protein assemblies and their remodeling during physiological processes
is fundamental to cells. Therefore, providing high-resolution snapshots of macromolecular …

Uncovering the mechanisms that underlie the biogenesis and maintenance of eukaryotic
organelles is a vibrant and essential area of biological research. In comparison, little …

Coxiella burnetii is an obligate zoonotic bacterium that targets macrophages causing a
disease called Q fever. It has a biphasic developmental life cycle where the extracellular and …

Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

Three-dimensional electron microscopy techniques like electron tomography provide
valuable insights into cellular structures, and present significant challenges for data storage …

A contractile sheath and rigid tube assembly is a widespread apparatus used by
bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell …

The bacterial flagellar type III secretion system (fT3SS) is a suite of membrane-embedded
and cytoplasmic proteins responsible for building the flagellar motility machinery …