The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology

SF Janssen, TGMF Gorgels, WD Ramdas… - Progress in retinal and …, 2013 - Elsevier
Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

A contemporary concept of the blood–aqueous barrier

TF Freddo - Progress in retinal and eye research, 2013 - Elsevier
This review traces the evolution of the concept of the blood–aqueous barrier (BAB) during
the past 20 years. The Classical model simply stipulated that the tight junctions of the iris …

[HTML][HTML] Proteome analysis of human aqueous humor

UR Chowdhury, BJ Madden… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: Human aqueous humor (hAH) provides nutrition and immunity within the anterior
chamber of the eye. Characterization of the protein composition of hAH will identify …

Human cornea proteome: identification and quantitation of the proteins of the three main layers including epithelium, stroma, and endothelium

TF Dyrlund, ET Poulsen, C Scavenius… - Journal of proteome …, 2012 - ACS Publications
Diseases of the cornea are common and refer to conditions like infections, injuries and
genetic defects. Morphologically, many corneal diseases affect only certain layers of the …

The human eye proteome project: updates on an emerging proteome

MT Ahmad, P Zhang, C Dufresne, L Ferrucci… - …, 2018 - Wiley Online Library
The human eye is a complex organ consisting of multiple compartments with unique and
specialized properties that reflect their varied functions. Although there have been …

[HTML][HTML] Alterations in the aqueous humor proteome in patients with a glaucoma shunt device

A Anshu, MO Price, MR Richardson, ZM Segu… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose To investigate whether implantation of a glaucoma shunt device leads to
inappropriate accumulation of plasma derived proteins in the aqueous humor. Methods …

The Human Eye Proteome Project: perspectives on an emerging proteome

RD Semba, JJ Enghild, V Venkatraman… - …, 2013 - Wiley Online Library
There are an estimated 285 million people with visual impairment worldwide, of whom 39
million are blind. The pathogenesis of many eye diseases remains poorly understood. The …

[HTML][HTML] Protein biomarkers in uveitis

R Bansal, A Gupta - Frontiers in Immunology, 2020 - frontiersin.org
The diseases affecting the retina or uvea (iris, ciliary body, or choroid) generate changes in
the biochemical or protein composition of ocular fluids/tissues due to disruption of blood …

Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome

AA Kliuchnikova, NI Samokhina, IY Ilina… - …, 2016 - Wiley Online Library
Twenty‐nine human aqueous humor samples from patients with eye diseases such as
cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by …

Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma

MD Pinazo-Durán, V Zanón-Moreno… - Current opinion in …, 2013 - Elsevier
There is growing interest on the correlation among oxidative stress, inflammation, apoptosis
and primary open-angle glaucoma initiation and progression. Reactive oxygen species are …