The developing oligodendrocyte: key cellular target in brain injury in the premature infant

JJ Volpe, HC Kinney, FE Jensen… - International Journal of …, 2011 - Elsevier
Brain injury in the premature infant, a problem of enormous importance, is associated with a
high risk of neurodevelopmental disability. The major type of injury involves cerebral white …

Infection-induced inflammation and cerebral injury in preterm infants

T Strunk, T Inder, X Wang, D Burgner… - The Lancet infectious …, 2014 - thelancet.com
Preterm birth and infectious diseases are the most common causes of neonatal and early
childhood deaths worldwide. The rates of preterm birth have increased over recent decades …

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

JR Buser, J Maire, A Riddle, X Gong… - Annals of …, 2012 - Wiley Online Library
Objective: The major form of magnetic resonance imaging–defined white matter injury (WMI)
comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is …

Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants

C Verney, A Monier, C Fallet‐Bianco… - Journal of …, 2010 - Wiley Online Library
Amoeboid microglial subpopulations visualized by antibodies against ionized calcium‐
binding adapter molecule 1, CD68, and CD45 enter the forebrain starting at 4.5 …

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

DF Niño, Q Zhou, Y Yamaguchi, LY Martin… - Science translational …, 2018 - science.org
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant.
One of the most important long-term complications observed in children who survive NEC …

Preterm brain Injury: White matter injury

J Schneider, SP Miller - Handbook of clinical neurology, 2019 - Elsevier
Despite the advances in neonatal intensive care, the preterm brain remains vulnerable to
white matter injury (WMI) and disruption of normal brain development (ie, dysmaturation) …

Oligodendrocyte development and myelination in neurodevelopment: molecular mechanisms in health and disease

A Barateiro, D Brites… - Current pharmaceutical …, 2016 - ingentaconnect.com
Oligodendrocytes are the myelinating cells of the central nervous system that constitute
about 5 to 10% of the total glial population. These cells are responsible for myelin sheath …

Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia

LJ Chew, P Fusar-Poli, T Schmitz - Developmental neuroscience, 2013 - karger.com
Schizophrenia is a chronic and debilitating mental illness characterized by a broad range of
abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as …

Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations

JD Reiss, LS Peterson, SN Nesamoney, AL Chang… - Experimental …, 2022 - Elsevier
Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …

Oligodendrocyte pathophysiology and treatment strategies in cerebral ischemia

G Mifsud, C Zammit, R Muscat… - CNS neuroscience & …, 2014 - Wiley Online Library
Oligodendrocytes (OL s), the myelin‐forming cells of the central nervous system, form a
functional unit with axons and play a crucial role in axonal integrity. An episode of hypoxia …