Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

The founding in 1965 of what is now called the Cambridge Structural Database (CSD) has
reaped dividends in numerous and diverse areas of chemical research. Each of the million …

Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Persistent excessive inflammation and oxidative stress are main causes for the impaired
wound healing in diabetic patient. To reduce the excessive reactive oxygen species (ROS) …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …