Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …

COVID-19 is associated with neurological complications including stroke, delirium and
encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …

Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Systemic autoimmune rheumatic diseases (SARDs) can lead to irreversible damage if left
untreated, yet these patients often endure long diagnostic journeys before being diagnosed …

Rheumatoid arthritis (RA) is a common autoimmune disease leading to pain, disability, and
even death. Although studies have revealed that aberrant activation of STING was …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …