[HTML][HTML] Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-
characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies …
characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies …
[HTML][HTML] Protein cargo in extracellular vesicles as the key mediator in the progression of cancer
K Hánělová, M Raudenská, M Masařík… - Cell Communication and …, 2024 - Springer
Exosomes are small vesicles of endosomal origin that are released by almost all cell types,
even those that are pathologically altered. Exosomes widely participate in cell-to-cell …
even those that are pathologically altered. Exosomes widely participate in cell-to-cell …
[HTML][HTML] Recent findings in the regulation of programmed death ligand 1 expression
X Shen, L Zhang, J Li, Y Li, Y Wang, ZX Xu - Frontiers in immunology, 2019 - frontiersin.org
With the recent approvals for the application of monoclonal antibodies that target the well-
characterized immune checkpoints, immune therapy shows great potential against both …
characterized immune checkpoints, immune therapy shows great potential against both …
[HTML][HTML] Gene interfered-ferroptosis therapy for cancers
J Gao, T Luo, J Wang - Nature communications, 2021 - nature.com
Although some effective therapies have been available for cancer, it still poses a great threat
to human health and life due to its drug resistance and low response in patients. Here, we …
to human health and life due to its drug resistance and low response in patients. Here, we …
[HTML][HTML] The mechanisms of PD-L1 regulation in non-small-cell lung cancer (NSCLC): which are the involved players?
G Lamberti, M Sisi, E Andrini, A Palladini, F Giunchi… - Cancers, 2020 - mdpi.com
Simple Summary Immunotherapy against PD-1/PD-L1 dramatically improved outcomes in
non-small cell lung cancer patients. These treatments are more effective the higher the …
non-small cell lung cancer patients. These treatments are more effective the higher the …
[HTML][HTML] In vitro and in vivo anti-inflammatory effects of polyphyllin VII through downregulating MAPK and NF-κB pathways
Background: Polyphyllin VII (PP7), a steroidal saponin from Paris polyphylla, has been
found to exert strong anticancer activity. Little is known about the anti-inflammatory property …
found to exert strong anticancer activity. Little is known about the anti-inflammatory property …
Organic/inorganic nanocomposites for cancer immunotherapy
M Hao, B Chen, X Zhao, N Zhao, FJ Xu - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Cancer immunotherapy provides an effective way to deal with cancer. Although
immunotherapy strategies have shown encouraging therapeutic effects, the inherent …
immunotherapy strategies have shown encouraging therapeutic effects, the inherent …
Identification of adipsin as a novel prognostic biomarker in patients with coronary artery disease
T Ohtsuki, K Satoh, T Shimizu, S Ikeda… - Journal of the …, 2019 - Am Heart Assoc
Background Circulating proteins are exposed to vascular endothelial layer and influence
their functions. Among them, adipsin is a member of the trypsin family of peptidases and is …
their functions. Among them, adipsin is a member of the trypsin family of peptidases and is …
Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways
Z Ruan, M Liang, L Shang, M Lai, X Deng, X Su - Pancreatology, 2021 - Elsevier
Background Pancreatic cancer (PC) is a highly fatal malignancy with few effective therapies
currently available. Recent studies have shown that PD-L1 inhibitors could be potential …
currently available. Recent studies have shown that PD-L1 inhibitors could be potential …
ELF3 Mediates IL-1α Induced Differentiation of Mesenchymal Stem Cells to Inflammatory iCAFs
LL Tran, T Dang, R Thomas, DR Rowley - Stem Cells, 2021 - academic.oup.com
Stromal cells in the tumor microenvironment regulate the immune landscape and tumor
progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is …
progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is …