Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

The innate immune mechanisms of the liver represent an important first line of defense
against bacterial products, toxins, and food antigens coming from the intestine. Natural Killer …

Patients with chronic active hepatitis C and cirrhosis often develop hepatocellular
carcinoma. Interferon (IFN) seems to be effective in some patients but whether it prevents …

Abstract Relatively few patients (≤ 20%) with chronic hepatitis C achieve a sustained
virological response after interferon-α monotherapy. Hence, alternative treatment strategies …

In this study, an impaired natural killer (NK) cell cytolytic activity in 135 hepatocellular
carcinoma (HCC) patients parallel to a reduced expression level of insulin-like growth factor …

Hepatocellular carcinoma (HCC) patients with reduced natural killer (NK)–cell numbers and
function have been shown to have a poor disease outcome. Mechanisms underlying NK-cell …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid
cell subsets that are key for the detection and elimination of pathogens and cancer cells. In …

There is now sufficient evidence to consider the pit cells as a hepatic, intrasinusoidal
population of large granular lymphocytes. They should be considered as resident sinusoidal …

According to the various surveys of the National Institute on Drug Abuse, particularly the
DAWN survey, and also the New York State Division of Substance Abuse Services, there are …

The landmark experiments by Isaacs and Lindenmann in 1957 demonstrated the existence
of a biologic substance, named interferon (IFN) because it'interfered'with viral replication in …