Autophagy is a process of self-degradation that plays an important role in removing
damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions …

An efficient synthetic route for the generation of BINOL-based porous organic polymers
(POPs) with hierarchical porosity has been developed. As opposed to BINOL-based POPs …

Cancer therapy is one of the most important challenges of modern medical and chemical
sciences. Among the many methods of combating cancer, chemotherapy plays a special …

It was established that the synthesis of hybrid molecules containing a thiazolidinone and a
(2 Z)-2-chloro-3-(4-nitrophenyl) prop-2-ene structural fragments is an effective approach for …

The discovery of cytotoxic drugs is focused on designing a compound structure that directly
affects cancer cells without an impact on normal cells. The mechanism of anticancer activity …

Based on the results of previous work, we designed and synthesized 1, 3, 4-thiadiazole
derivatives. The cytotoxic activity of the obtained compounds was then determined in …

Colon cancer remains one of the main cancers causing death in men and women worldwide
as certain colon cancer subtypes are resistant to conventional treatments and the …

Transition metal coordination compounds play an important role in the treatment of
neoplastic diseases. However, due to their low selectivity and bioavailability, as well as the …

Natural products play an important role in drug development and lead compound synthesis.
Neocryptolepine is a polycyclic quinoline compound isolated from Cryptolepis sanguinolent …

Nowadays, cancer represents one of the major causes of death in humans worldwide, which
renders the quest for new and improved antineoplastic agents to become an urgent issue in …