Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

The causes of most neurological disorders are not fully understood. Inflammation and blood–
brain barrier dysfunction appear to play major roles in the pathology of these diseases …

Blood-based biomarkers present a considerable challenge: technically, as blood is a
complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless …

Neurofibrillary tangles are associated with cognitive dysfunction, and hippocampal atrophy
with increased CSF tau markers. However, the plasma tau levels of Alzheimer's disease …

Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are gaining
increasing relevance in our aging society. However, the complex multifactorial mechanisms …

Vascular dysfunction is emerging as a key pathological hallmark in Alzheimer's disease
(AD). A leaky blood–brain barrier (BBB) has been described in AD patient tissue and in vivo …

Amyloid-beta (Aβ) with 40 (Aβ40) and 42 (Aβ42) amino acids, the main components of
amyloid plaques in the Alzheimer's disease (AD) brain, can be measured in human …

Alzheimer's disease is a devastating cureless neurodegenerative disorder affecting> 35
million people worldwide. The disease is caused by toxic oligomers and aggregates of …