Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …

Alarmins are preformed, endogenous molecules that can be promptly released to signal cell
or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

Organelle-targeted photosensitization represents a promising approach in photodynamic
therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we …

Background The 2019 novel coronavirus disease (COVID-19) causes for unresolved
reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to …

A key question in immunology concerns how sterile injury activates innate immunity to
mediate damaging inflammation in the absence of foreign invaders. The discovery that …

The immune system has evolved to respond not only to pathogens, but also to signals
released from dying cells. Cell death through necrosis induces inflammation, whereas …