MicroRNAs (miRNAs) are endogenous noncoding single-stranded small RNAs of~ 22
nucleotides in length that post-transcriptionally repress the expression of their various target …

Abstract The Epithelial Na+ Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes
δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It …

Aldosterone is a mineralocorticoid hormone produced in the zona glomerulosa of the
adrenal cortex that influences water and salt regulation in the body. Aldosterone's primary …

BACKGROUND: Excess aldosterone is implicated in vascular calcification (VC), but the
mechanism by which aldosterone-MR (mineralocorticoid receptor) complex promotes VC is …

The final steps in the R enin-A ngiotensin-A ldosterone signaling S ystem (RAAS) involve
binding of the corticosteroid hormone, aldosterone to its mineralocorticoid receptor (MR) …

MicroRNAs, the endogenous mediators of RNA interference, interact with the renin-
angiotensin-aldosterone system, regulate aldosterone secretion and aldosterone effects …

Amiloride-sensitive epithelial sodium (Na+) channels (ENaC) play a crucial role in Na+
transport and fluid reabsorption in the kidney, lung, colon, vasculature, and immune system …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid‐base balance in response to changes in …

Aldosterone is a cardiovascular hormone with a key role in blood pressure regulation,
among other processes, mediated through its targeting of the mineralocorticoid receptor in …

The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that transduces
the effects of aldosterone and glucocorticoids in a tissue-and cell type-specific ways …