Chemical synthesis and molecular docking study of new thiazole, thiophene, and thieno [2, 3-d] pyrimidine derivatives as potential antiproliferative and antimicrobial …
IMM Othman, ZM Alamshany, NY Tashkandi… - Journal of Molecular …, 2022 - Elsevier
This context deals with the design and synthesis of a new set of derivatives containing
thiazole, thiophene, and thieno [2, 3-d] pyrimidine motifs 3-13 starting with 2-((2 …
thiazole, thiophene, and thieno [2, 3-d] pyrimidine motifs 3-13 starting with 2-((2 …
Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of …
AH Abdelmonsef, AM El-Saghier… - Green Chemistry Letters …, 2023 - Taylor & Francis
The overexpression of Rab proteins was linked to cancer development, making this family of
proteins an attractive drug target for the identification of novel inhibitors against tumor …
proteins an attractive drug target for the identification of novel inhibitors against tumor …
[HTML][HTML] Synthesis and molecular docking of some novel 3-thiazolyl-coumarins as inhibitors of VEGFR-2 kinase
One crucial strategy for the treatment of breast cancer involves focusing on the Vascular
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …
[HTML][HTML] Synthesis, molecular docking, and dynamic simulation targeting main protease (Mpro) of new, thiazole clubbed pyridine scaffolds as potential COVID-19 …
Many biological activities of pyridine and thiazole derivatives have been reported, including
antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we …
antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we …
[HTML][HTML] Three-component synthesis of some new coumarin derivatives as anticancer agents
LA Alshabanah, LA Al-Mutabagani, SM Gomha… - Frontiers in …, 2022 - frontiersin.org
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing
acetylcoumarin synthon, under ultrasonic irradiation was developed using chitosan-grafted …
acetylcoumarin synthon, under ultrasonic irradiation was developed using chitosan-grafted …
[HTML][HTML] New amino acid Schiff bases as anticancer agents via potential mitochondrial complex I-associated hexokinase inhibition and targeting AMP-protein kinases …
Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
Design, synthesis and molecular docking of novel substituted azepines as inhibitors of PI3K/Akt/TSC2/mTOR signaling pathway in colorectal carcinoma
A series of novel substituted azepines (2–7) was synthesized using both traditional and
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …
Novel thiadiazole-thiazole hybrids: Synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
[HTML][HTML] Green Synthesis and molecular docking study of some new thiazoles using terephthalohydrazide chitosan hydrogel as ecofriendly biopolymeric catalyst
Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
[HTML][HTML] Synthesis and biological evaluation of thiazolyl-ethylidene hydrazino-thiazole derivatives: a novel heterocyclic system
LA Al-Mutabagani, FM Abdelrazek, SM Gomha… - Applied Sciences, 2021 - mdpi.com
The reaction of 2-(1-(2-(2-(4-methoxybenzylidene) hydrazinyl)-4-methylthiazol-5-yl)
ethylidene) hydrazinecarbothioamide with a range of hydrazonoyl chlorides and α-halo …
ethylidene) hydrazinecarbothioamide with a range of hydrazonoyl chlorides and α-halo …