Amiodarone, a bi-iodinated benzofuran derivative, is, because of its high effectiveness, one
of the most widely used antiarrhythmic agents. However, adverse effects, especially …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
progressive loss of pulmonary function. Drug-induced interstitial lung disease has been …

Interstitial pulmonary fibrosis (IPF) is scarring of the lung caused by a variety of inhaled
agents including mineral particles, organic dusts, and oxidant gases. The disease afflicts …

We have studied whether curcumin prevents amiodarone‐induced lung fibrosis in rats.
Intratracheal instillation of amiodarone (6.25 mg kg− 1 on days 0 and 2, and then killed on …

The molecular cloning of a group of proteins, collectively referred to as cytokines, and
including interleukins, chemokines, growth factors, colony stimulating factors, and tumor …

Abstract Amiodarone [2-butyl-3-(3′, 5′-diiodo-4'α-diethylaminoethoxybenzoyl)-
benzofuran](AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic …

Patients with QT prolongation have delayed cardiac repolarization and may suffer fatal
ventricular arrhythmias. To determine the role of cytokines in causing this syndrome, we …

Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …

Amiodarone (AMD), an antiarrhythmic drug, is used cautiously due to its lung toxicity that is
characterized by alveolar inflammation followed by fatal fibrosis. AMD induces lung …

The long‐term side effect of the antiarrhythmic drug, amiodarone (AMIO), such as lung
toxicity, remains a critical clinical issue. The previous knowledge denotes diverse …