The roles of nitric oxide synthase/nitric oxide pathway in the pathology of vascular dementia and related therapeutic approaches
HY Zhu, FF Hong, SL Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …
caused by cerebrovascular disease, and patients often show severe impairments of …
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases
AA Mangoni, A Zinellu - Frontiers in Immunology, 2023 - frontiersin.org
There is an increasing interest in the pathophysiological role of the kynurenine pathway of
tryptophan metabolism in the regulation of immune function and inflammation. We sought to …
tryptophan metabolism in the regulation of immune function and inflammation. We sought to …
Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid‐induced model of Huntington's disease
PE Martínez‐Gopar… - Journal of …, 2022 - Wiley Online Library
Huntington´ s disease (HD) is a pathological condition that can be studied in mice by the
administration of quinolinic acid (QUIN), an agonist of the N‐methyl‐d‐aspartate receptor …
administration of quinolinic acid (QUIN), an agonist of the N‐methyl‐d‐aspartate receptor …
Toll-like receptor 4 plays a significant role in the biochemical and neurological alterations observed in two distinct mice models of Huntington's disease
PE Martínez-Gopar, MJ Pérez-Rodríguez… - Molecular …, 2023 - Springer
Toll-like receptors (TLRs) are central players in innate immunity responses. They are
expressed in glial cells and neurons, and their overactivation leads to the production of …
expressed in glial cells and neurons, and their overactivation leads to the production of …
MM165-a small hybrid molecule modulates the kynurenine pathway and attenuates lipopolysaccharide-induced memory deficits and inflammation
M Kotańska, M Łanocha, M Bednarski… - Neurochemical …, 2024 - Springer
Cognitive dysfunctions are now recognized as core symptoms of various psychiatric
disorders eg, major depressive disorder. Sustained immune activation may leads to …
disorders eg, major depressive disorder. Sustained immune activation may leads to …
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
Background NOS1AP is an adaptor protein and its SNP rs12742393 was associated with
type 2 diabetes (T2D). However, it remains uncertain whether NOS1AP plays a role in …
type 2 diabetes (T2D). However, it remains uncertain whether NOS1AP plays a role in …
Estrogen can promote the expression of genes related to precocious puberty in GT1-7 mouse hypothalamic GnRH neuronal cell line via activating G protein-coupled …
F Qian, N Shi, H Zhou - General Physiology & Biophysics, 2020 - search.ebscohost.com
The G protein-coupled estrogen receptor (GPER) was proved to be a new type of estrogen
receptor (ER). It is unknown that whether estrogen can regulate the secretion of …
receptor (ER). It is unknown that whether estrogen can regulate the secretion of …
Effects of Quinolinate-Induced Lesion of the Medial Prefrontal Cortex on Prefrontal and Striatal Concentrations of d-Serine in the Rat
A Umino, H Iwama, M Umino, D Shimazu… - Neurochemical …, 2022 - Springer
Abstract d-Serine has been shown to play an important role in the expression and control of
a variety of brain functions by acting as the endogenous coagonist for the N-methyl-d …
a variety of brain functions by acting as the endogenous coagonist for the N-methyl-d …
The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches
Z Han-Yan, H Fen-Fang… - International Journal of …, 2021 - search.proquest.com
Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …
caused by cerebrovascular disease, and patients often show severe impairments of …