The roles of nitric oxide synthase/nitric oxide pathway in the pathology of vascular dementia and related therapeutic approaches

HY Zhu, FF Hong, SL Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …

A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases

AA Mangoni, A Zinellu - Frontiers in Immunology, 2023 - frontiersin.org
There is an increasing interest in the pathophysiological role of the kynurenine pathway of
tryptophan metabolism in the regulation of immune function and inflammation. We sought to …

Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid‐induced model of Huntington's disease

PE Martínez‐Gopar… - Journal of …, 2022 - Wiley Online Library
Huntington´ s disease (HD) is a pathological condition that can be studied in mice by the
administration of quinolinic acid (QUIN), an agonist of the N‐methyl‐d‐aspartate receptor …

Toll-like receptor 4 plays a significant role in the biochemical and neurological alterations observed in two distinct mice models of Huntington's disease

PE Martínez-Gopar, MJ Pérez-Rodríguez… - Molecular …, 2023 - Springer
Toll-like receptors (TLRs) are central players in innate immunity responses. They are
expressed in glial cells and neurons, and their overactivation leads to the production of …

MM165-a small hybrid molecule modulates the kynurenine pathway and attenuates lipopolysaccharide-induced memory deficits and inflammation

M Kotańska, M Łanocha, M Bednarski… - Neurochemical …, 2024 - Springer
Cognitive dysfunctions are now recognized as core symptoms of various psychiatric
disorders eg, major depressive disorder. Sustained immune activation may leads to …

Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

K Mu, Y Sun, Y Zhao, T Zhao, Q Li, M Zhang, H Li… - …, 2019 - thelancet.com
Background NOS1AP is an adaptor protein and its SNP rs12742393 was associated with
type 2 diabetes (T2D). However, it remains uncertain whether NOS1AP plays a role in …

Estrogen can promote the expression of genes related to precocious puberty in GT1-7 mouse hypothalamic GnRH neuronal cell line via activating G protein-coupled …

F Qian, N Shi, H Zhou - General Physiology & Biophysics, 2020 - search.ebscohost.com
The G protein-coupled estrogen receptor (GPER) was proved to be a new type of estrogen
receptor (ER). It is unknown that whether estrogen can regulate the secretion of …

Effects of Quinolinate-Induced Lesion of the Medial Prefrontal Cortex on Prefrontal and Striatal Concentrations of d-Serine in the Rat

A Umino, H Iwama, M Umino, D Shimazu… - Neurochemical …, 2022 - Springer
Abstract d-Serine has been shown to play an important role in the expression and control of
a variety of brain functions by acting as the endogenous coagonist for the N-methyl-d …

The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches

Z Han-Yan, H Fen-Fang… - International Journal of …, 2021 - search.proquest.com
Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …