Inflammation and premature ageing in chronic kidney disease
T Ebert, SC Pawelzik, A Witasp, S Arefin, S Hobson… - Toxins, 2020 - mdpi.com
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …
phenotype and contribute to impaired health status, reduced quality of life, and premature …
Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients …
S Yamada, K Tsuruya, T Kitazono, T Nakano - Clinical and Experimental …, 2022 - Springer
Chronic kidney disease–mineral and bone disorder (CKD–MBD) is a systemic disorder that
affects multiple organs and systems and increases the risk of morbidity and mortality in …
affects multiple organs and systems and increases the risk of morbidity and mortality in …
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Y Moritoh, S Abe, H Akiyama, A Kobayashi… - Nature …, 2021 - nature.com
Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
A randomized trial of tenapanor and phosphate binders as a dual-mechanism treatment for hyperphosphatemia in patients on maintenance dialysis (AMPLIFY)
PE Pergola, DP Rosenbaum, Y Yang… - Journal of the …, 2021 - journals.lww.com
Background Hyperphosphatemia is associated with cardiovascular morbidity and mortality
in patients receiving maintenance dialysis. It is unknown whether combining two therapies …
in patients receiving maintenance dialysis. It is unknown whether combining two therapies …
Remediation of water containing phosphate using ceria nanoparticles decorated partially reduced graphene oxide (CeO2-PRGO) composite
Phosphate pollution from point and discrete sources is a serious threat to the aquatic
ecosystem in both industrialized and developing countries. The release of excessive …
ecosystem in both industrialized and developing countries. The release of excessive …
Nrf2 in early vascular ageing: Calcification, senescence and therapy
S Arefin, S Buchanan, S Hobson, J Steinmetz… - Clinica Chimica …, 2020 - Elsevier
Under normal physiological conditions, free radical generation and antioxidant defences are
balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a …
balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a …
Heparin immobilized graphene oxide in polyetherimide membranes for hemodialysis with enhanced hemocompatibility and removal of uremic toxins
NJ Kaleekkal - Journal of Membrane Science, 2021 - Elsevier
Intermittent hemodialysis is a life-saving renal replacement therapy that removes excess
water and uremic salts from patients who suffer from loss of kidney function …
water and uremic salts from patients who suffer from loss of kidney function …
An update on phosphate binders for the treatment of hyperphosphatemia in chronic kidney disease patients on dialysis: a review of safety profiles
H Ogata, A Takeshima, H Ito - Expert opinion on drug safety, 2022 - Taylor & Francis
Introduction Hyperphosphatemia is an inevitable complication for patients undergoing
dialysis, as is the resulting need for treatment with phosphate binders. Currently, various …
dialysis, as is the resulting need for treatment with phosphate binders. Currently, various …
Phosphate, microbiota and CKD
Phosphate is a key uremic toxin associated with adverse outcomes. As chronic kidney
disease (CKD) progresses, the kidney capacity to excrete excess dietary phosphate …
disease (CKD) progresses, the kidney capacity to excrete excess dietary phosphate …