The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms

Y Liang, X Dai, Y Cao, X Wang, J Lu, L Xie, K Liu, X Li - Biochimie, 2023 - Elsevier
The global epidemic of diabetes has brought heavy pressure on public health. New effective
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …

[HTML][HTML] Long-term treatment of postmenopausal osteoporosis

JP Brown - Endocrinology and Metabolism, 2021 - synapse.koreamed.org
Osteoporosis is an incurable chronic condition, like heart disease, diabetes, or hypertension.
A large gap currently exists in the primary prevention of fractures, and studies show that an …

[HTML][HTML] How to implement guidelines and models of care

P Geusens, NM Appelman-Dijkstra, MC Zillikens… - Best Practice & …, 2022 - Elsevier
In subjects older than 50 years, the presence of clinical risk factors (CRFs) for fractures or a
recent fracture is the cornerstone for case finding. In patients who are clinically at high short …

Development of an open-source measurement system to assess the areal bone mineral density of the proximal femur from clinical CT images

K Uemura, Y Otake, M Takao, H Makino, M Soufi… - Archives of …, 2022 - Springer
Commercial software is generally needed to measure the areal bone mineral density
(aBMD) of the proximal femur from clinical computed tomography (CT) images. This study …

[HTML][HTML] The synergistic treatment of cyclolinopeptide J and calcium carbonate nanoparticles for osteoporosis via BMP/Wnt signaling: In vivo and in vitro

J Chen, W Li, YY Lee, Z Cai, J Chen, Y Wang - Journal of Functional Foods, 2023 - Elsevier
This research focuses on the investigation of cyclolinopeptide J (CLJ), a bioactive peptide
naturally present in flaxseed, which loaded in porous calcium carbonate (CA) nanoparticles …

Causal effects of plasma Proteome on osteoporosis and osteoarthritis

BX Han, SS Yan, Y Han, Q Xu, QG Zhao, XL Ma… - Calcified tissue …, 2023 - Springer
The two-sample Mendelian randomization (MR) study revealed a causal association of
plasma proteins with osteoporosis (OP) and osteoarthritis (OA). Bone mineral density (BMD) …

Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice

C Jeong, CH Lee, Y Lee, J Seo, W Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ulmus macrocarpa Hance (UmH) bark has been
traditionally utilized for medicinal purposes. The bark extract of this plant has diverse health …

[HTML][HTML] Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES …

J Tao, Z Yan, W Huang, T Feng - Frontiers in Medicine, 2023 - frontiersin.org
Background Some studies had reported that patients with viral hepatitis are at increased risk
of reduced bone mineral density and even osteoporosis. However, the interaction between …

[HTML][HTML] Development and validation of an open-source tool for opportunistic screening of osteoporosis from hip CT images: a multicentre study of 978 hips

K Uemura, Y Otake, K Takashima… - Bone & Joint …, 2023 - boneandjoint.org.uk
Aims This study aimed to develop and validate a fully automated system that quantifies
proximal femoral bone mineral density (BMD) from CT images. Methods The study analyzed …

Flavonoid Glycosides from Ulmus macrocarpa Inhibit Osteoclast Differentiation via the Downregulation of NFATc1

W Wang, C Jeong, Y Lee, C Park, E Oh, KH Park… - ACS …, 2022 - ACS Publications
The aim of this study was to isolate and identify chemical components with osteoclast
differentiation inhibitory activity from Ulmus macrocarpa Hance bark. Spectroscopic …