Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including
bone cells. Mutations in App gene result in early-onset Alzheimer's disease (AD). However …

Background: The molecular mechanisms underlying Alzheimer's disease (AD) are yet to be
fully elucidated. The so-called “amyloid cascade hypothesis” has long been the prevailing …

Alzheimer's disease (AD) is the most frequent cause of dementia worldwide and represents
one of the leading factors for severe disability in older persons. Although its etiology is not …

Tropomyosin, a major allergen of shrimp, presents high stability to various conditions owing
to the high content of α-helix. Chemical modification of tropomyosin can induce structural …

First‐hand and second‐hand tobacco smoke are causally linked to a huge number of deaths
and are responsible for a broad spectrum of pathologies such as cancer, cardiovascular …

Progressive memory loss and cognitive impairment are the main clinical manifestations of
Alzheimer's disease (AD). Currently, there is no effective drug available for the treatment of …

Abstract Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible
for the intramembraneous cleavage of more than 90 type I transmembrane proteins …

Abstract Alzheimer's disease (AD), and many neurodegenerative disorders, are
multifactorial in nature. They involve a combination of genomic, epigenomic, interactomic …

Aging-associated declines in cognitive, emotional, and cardiovascular function are well
known. Environmental stress triggers critical changes in the brain, further compromising …

Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of
rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine …