To determine whether glutathione (GSH) loss or increased reactive oxygen species (ROS)
are more important to neuron loss, aging, and Alzheimer's disease (AD), we stressed or …

One of the characteristic features of the aging is dysfunction of mitochondria. Its role in the
regulation of metabolism and apoptosis suggests a possible link between these cellular …

Pathophysiological evidence correlating locus ceruleus neuron loss with increased
Alzheimer's disease pathology suggests that norepinephrine (NE) is neuroprotective. Here …

Translation of genetic information into functional proteins is critical for all cellular life.
Accurate protein synthesis relies on proper aminoacylation of transfer RNAs (tRNAs) and …

Oxidative stress is an early hallmark in neurodegenerative disorders such as Alzheimer's
and Parkinson's diseases. However, the critical biochemical effector mechanisms of …

Albumin is one of the copious and important plasma proteins which takes an active part in
transporting therapeutic agents, neutralization of toxins, protection from inflammation, and …

Alzheimer's disease (AD) is a difficult puzzle to solve, in part because the etiology of this
devastating neurodegenerative disorder remains murky. However, diabetes has been …

Neurodegenerative disorders are undoubtedly an increasing problem in the health
sciences, given the increase of life expectancy and occasional vicious life style. Despite the …

Microglial activation plays an important role in neurodegenerative diseases associated with
oxidative stress. tert-Butyl hydroperoxide (t-BHP), an analog of hydroperoxide, mimics the …

Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and
known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer's …