The chromatin‐regulatory principles of histone post‐translational modifications (PTMs) are
discussed with a focus on the potential alterations in chromatin functional state due to steric …

Background Apart the gene-regulatory functions as docking sites for histone 'readers', some
histone modifications could directly affect nucleosome structure. The H2BK34-ubiquitylation …

In addition to chemical modifications such as acetylation or methylation, histones are
modified by the addition of small polypeptides such as ubiquitin. Whereas poly …

Chromatin proteins play a role in the organization and functions of DNA. Covalent
modifications of nuclear proteins modulate their interactions with DNA sequences and are …

To gain insight into the significance of nuclear ubiquitinated proteins, two serial extracts
prepared from various leukemic cells were analysed by western blotting with anti-ubiquitin …

We investigated early alterations in rat neurons after experimental ischemic stress. Transient
ischemia was generated by bilateral occlusion of the carotids after hypoxia. Data show a …

Publisher Summary This chapter presents a structural overview of the modifications of a
primary structure and discusses the modifications at the posttranslational level that …

Publisher Summary This chapter presents four histone modifications and their functions in
chromatin structure and function. The four core histones—H2A, H2B, H3, H4—and their …

Effector proteins are recruited to chromatin via transient interactions between their reader
domains and histone post-translational modification (PTM) patterns. These interactions form …

Ironically, it is hard to believe that this era is coming to an end. The obvious point is that it
took a lot longer than anyone could ever have anticipated. The lessons I gained along the …