Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves
dynamic changes in cytoskeleton architecture during mesenchymal condensation before …

Repair of large bone defects represents a major challenge for orthopedic surgeons. The
newly formed microvessels inside grafts play a crucial role in successful bone tissue …

Photodynamic therapy is an effective alternative to traditional treatments due to its minimally
invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug …

The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

Background & Aims Mechanical forces contribute to portal hypertension (PHTN) and
fibrogenesis. We investigated the mechanisms by which forces are transduced by liver …