Why breed disease-resilient livestock, and how?

PW Knap, A Doeschl-Wilson - Genetics Selection Evolution, 2020 - Springer
Background Fighting and controlling epidemic and endemic diseases represents a
considerable cost to livestock production. Much research is dedicated to breeding disease …

Genome editing of pigs for agriculture and biomedicine

H Yang, Z Wu - Frontiers in Genetics, 2018 - frontiersin.org
Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle

L Fang, W Cai, S Liu, O Canela-Xandri, Y Gao… - Genome …, 2020 - genome.cshlp.org
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated …

[HTML][HTML] CRISPR/Cas9 systems: delivery technologies and biomedical applications

Y Du, Y Liu, J Hu, X Peng, Z Liu - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …

Invited review: Opportunities for genetic improvement toward higher prolificacy in sheep

E Gootwine - Small Ruminant Research, 2020 - Elsevier
Breeding for higher prolificacy may improve lamb production efficiency in semi-intensive and
intensive sheep-production systems. Crossbreeding of native breeds with exotic prolific …

Enhancing the nutritional value of red meat through genetic and feeding strategies

M Juárez, S Lam, BM Bohrer, MER Dugan, P Vahmani… - Foods, 2021 - mdpi.com
Consumption of red meat contributes to the intake of many essential nutrients in the human
diet including protein, essential fatty acids, and several vitamins and trace minerals, with …

Invited review: Reproductive and genomic technologies to optimize breeding strategies for genetic progress in dairy cattle

A Fleming, EA Abdalla, C Maltecca… - Archives Animal …, 2018 - aab.copernicus.org
Dairy cattle breeders have exploited technological advances that have emerged in the past
in regards to reproduction and genomics. The implementation of such technologies in …

[HTML][HTML] The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis

S Devkota - BMB reports, 2018 - ncbi.nlm.nih.gov
Non-homologous end joining (NHEJ), and to a lesser extent, the error-free pathway known
as homology-directed repair (HDR) are cellular mechanisms for recovery from double-strand …

Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer

LN Moro, DL Viale, JI Bastón, V Arnold, M Suvá… - Scientific reports, 2020 - nature.com
The application of new technologies for gene editing in horses may allow the generation of
improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a …

Application of gene editing technology in resistance breeding of livestock

S Wang, Z Qu, Q Huang, J Zhang, S Lin, Y Yang… - Life, 2022 - mdpi.com
As a new genetic engineering technology, gene editing can precisely modify the specific
gene sequence of the organism's genome. In the last 10 years, with the rapid development …