Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing
aggregated Aβ from the brains of symptomatic patients can slow the progression of …

The innate immune compartment of the human central nervous system (CNS) is highly
diverse and includes several immune-cell populations such as macrophages that are …

The arachnoid barrier delineates the border between the central nervous system and dura
mater. Although the arachnoid barrier creates a partition, communication between the …