Pre-eclampsia

E Dimitriadis, DL Rolnik, W Zhou… - Nature reviews Disease …, 2023 - nature.com
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

P Li, H Wang, L Guo, X Gou, G Chen, D Lin, D Fan… - BMC medicine, 2022 - Springer
Background Several recent observational studies have reported that gut microbiota
composition is associated with preeclampsia. However, the causal effect of gut microbiota …

Periodontitis and gestational diabetes mellitus: a potential inflammatory vicious cycle

MJ Bendek, G Canedo-Marroquín, O Realini… - International Journal of …, 2021 - mdpi.com
Periodontitis is a chronic inflammatory immune disease associated with a dysbiotic state,
influenced by keystone bacterial species responsible for disrupting the periodontal tissue …

[HTML][HTML] Investigating causal associations among gut microbiota, gut microbiota-derived metabolites, and gestational diabetes mellitus: a bidirectional Mendelian …

X Wu, D Lin, Q Li, J Cai, H Huang, T Xiang… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
Background: Previous studies have shown that gut microbiota (GM) and gut microbiota-
derived metabolites are associated with gestational diabetes mellitus (GDM). However, the …

Atractylenolide inhibits apoptosis and oxidative stress of HTR-8/SVneo cells by activating MAPK/ERK signalling in preeclampsia

M Liu, R Wang, J Xing, Y Tang - Phytomedicine, 2021 - Elsevier
Background Preeclampsia (PE) is a severe hypertension-related disorder occurring during
pregnancy that leads to significant mortality and morbidity in both the foetus and mother …

[HTML][HTML] Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

X Wu, Q Li, D Lin, J Cai, H Huang, H Tan - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Background: Recent studies have shown that gut microbiota (GM) is related to hypertensive
disorders in pregnancy (HDP). However, the causal relationship needs to be treated with …

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

JA Ishimwe - Physiological reports, 2021 - Wiley Online Library
Preeclampsia is a devastating hypertensive pregnancy disorder that currently affects 2%–
8% of pregnancies worldwide. It is associated with maternal and fetal mortality and morbidity …

Stimulation of α7 nicotinic acetylcholine receptor by nicotine suppresses decidual M1 macrophage polarization against inflammation in lipopolysaccharide-induced …

X Han, W Li, P Li, Z Zheng, B Lin, B Zhou… - Frontiers in …, 2021 - frontiersin.org
Changes in decidual macrophage polarization affect local inflammatory microenvironment
and lead to adverse pregnancy outcomes. However, the regulatory mechanism of …

Roles of human trophoblasts' pattern recognition receptors in host defense and pregnancy complications

K Motomura, M Hara, I Ito, H Morita… - Journal of Reproductive …, 2023 - Elsevier
The immune system in pregnancy is able to protect pregnant mothers and fetuses from
pathogenic microorganisms even while permitting the mother to tolerate the semi-allogenic …

Modeling trophoblast cell-guided uterine spiral artery transformation in the rat

V Shukla, MJ Soares - International Journal of Molecular Sciences, 2022 - mdpi.com
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion
and trophoblast-guided uterine spiral artery remodeling, which resembles human …