Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …

Biallelic loss-of-function variants in SMPD4 cause a rare and severe neurodevelopmental
disorder with progressive congenital microcephaly and early death. SMPD4 encodes a …

The nuclear pore complex (NPC) is the central portal for macromolecular exchange between
the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear …

Dopamine (DA) is a neurotransmitter that also acts as a neuromodulator, with both functions
being essential to brain function. Here, we present the first experimental measurement of DA …

Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and built from∼ 30
different nucleoporins (Nups) in multiple copies, few are integral membrane proteins. One of …

SMPD4 is a neutral sphingomyelinase implicated in a specific type of congenital
microcephaly. Although not intensively studied, SMPD4 deficiency has also been found to …

Junctions between the endoplasmic reticulum (ER) and the outer membrane of the nuclear
envelope (NE) physically connect both organelles. These ER–NE junctions are essential for …

Abstract Sphingomyelin phosphodiesterase 4 (SMPD4) encodes a member of the Mg2+-
dependent, neutral sphingomyelinase family that catalyzes the hydrolysis of the …

Nuclear cytoplasmic transport is mediated by many receptors that recognize specific nuclear
localization signals on proteins and RNA and transport these substrates through nuclear …