Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease

L Badimon, R Bugiardini, E Cenko… - European heart …, 2017 - academic.oup.com
The epidemic of obesity is recognized as one of the most important public health problems
facing the world today. According to 2014 World Health Organization (WHO) data, 1 39% of …

[HTML][HTML] Dietary nitrate intake in relation to the risk of dementia and imaging markers of vascular brain health: a population-based study

TOE de Crom, L Blekkenhorst, MW Vernooij… - The American Journal of …, 2023 - Elsevier
Background Nitric oxide is a free radical that can be produced from dietary nitrate and
positively affects cardiovascular health. With cardiovascular health playing an important role …

Exercise interventions and peripheral arterial function: implications for cardio-metabolic disease

SA Phillips, AM Mahmoud, MD Brown… - Progress in cardiovascular …, 2015 - Elsevier
Physical inactivity is a major risk factor for the development of obesity and other
cardiovascular (CV) disease (CVD). Vascular endothelial dysfunction is a key event in the …

Exercise as a therapeutic strategy for sarcopenia in heart failure: insights into underlying mechanisms

J Cho, Y Choi, P Sajgalik, MH No, SH Lee, S Kim… - Cells, 2020 - mdpi.com
Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a
gradual loss of skeletal muscle, leading to the decline of muscle strength and physical …

Endothelial autophagy in coronary microvascular dysfunction and cardiovascular disease

F Zhao, G Satyanarayana, Z Zhang, J Zhao, XL Ma… - Cells, 2022 - mdpi.com
Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional
disorders of coronary microcirculation that lead to impaired coronary blood flow and …

Impairment of Flow-Sensitive Inwardly Rectifying K+ Channels via Disruption of Glycocalyx Mediates Obesity-Induced Endothelial Dysfunction

IS Fancher, E Le Master, SJ Ahn… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: To determine if endothelial dysfunction in a mouse model of diet-induced obesity
and in obese humans is mediated by the suppression of endothelial Kir (inwardly rectifying …

Air pollution-induced vascular dysfunction: potential role of endothelin-1 (ET-1) system

J Finch, DJ Conklin - Cardiovascular toxicology, 2016 - Springer
Exposure to air pollution negatively impacts cardiovascular health. Studies show that
increased exposure to a number of airborne pollutants increases the risk for cardiovascular …

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

OA Savcheniuk, OV Virchenko, TM Falalyeyeva… - EPMA Journal, 2014 - Springer
Introduction Obesity becomes endemic today. Monosodium glutamate was proved as
obesogenic food additive. Probiotics are discussed to impact on obesity development. Aims …

Nitric oxide and the cardiovascular system

HG Bohlen - Comprehensive Physiology, 2011 - Wiley Online Library
Nitric oxide (NO) generated by endothelial cells to relax vascular smooth muscle is one of
the most intensely studied molecules in the past 25 years. Much of what is known about NO …

Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2. 1 and alterations to the glycocalyx

SJ Ahn, E Le Master, JC Lee… - American Journal …, 2022 - journals.physiology.org
Obesity imposes well-established deficits to endothelial function. We recently showed that
obesity-induced endothelial dysfunction was mediated by disruption of the glycocalyx and a …