Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …
aroused great interest in medicinal chemists for the development of new drugs or drug …
MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer
Y Lu, T Qin, J Li, L Wang, Q Zhang, Z Jiang… - Cancer gene therapy, 2017 - nature.com
MicroRNAs (miRNAs) have been proven to be involved in cell metastasis and angiogenesis
by interaction with the target mRNAs. Evidence has been confirmed that miR-140-5p is a …
by interaction with the target mRNAs. Evidence has been confirmed that miR-140-5p is a …
eIF4E–from translation to transformation
Y Mamane, E Petroulakis, L Rong, K Yoshida, LW Ler… - Oncogene, 2004 - nature.com
Over the years, studies have focused on the transcriptional regulation of oncogenesis. More
recently, a growing emphasis has been placed on translational control. The Ras and Akt …
recently, a growing emphasis has been placed on translational control. The Ras and Akt …
Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results
Purpose We studied the safety, clinical activity, and pharmacokinetics (PK) of AG-013736,
an oral receptor tyrosine kinase inhibitor of vascular endothelial cell growth factor, platelet …
an oral receptor tyrosine kinase inhibitor of vascular endothelial cell growth factor, platelet …
Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer
N Wang, ZY Wang, SL Mo, TY Loo, DM Wang… - Breast cancer research …, 2012 - Springer
Anti-angiogenesis targeting VEGFR-2 has been considered as an important strategy for
cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and …
cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and …
Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
BACKGROUND: Due to a dismal prognosis of advanced lung cancer, novel screening tools
and more effective treatments are clearly needed. Lately, an increasing number of tumour …
and more effective treatments are clearly needed. Lately, an increasing number of tumour …
Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment
MM Welle, CR Bley, J Howard… - Veterinary …, 2008 - Wiley Online Library
Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple
cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs …
cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs …
[HTML][HTML] Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products
M Kaur, C Agarwal, R Agarwal - The Journal of nutrition, 2009 - Elsevier
With emerging trends in the incidence of cancer of various organ sites, additional
approaches are needed to control human malignancies. Intervention or prevention of cancer …
approaches are needed to control human malignancies. Intervention or prevention of cancer …
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation …
AN Siddique, S Nunna, A Rajavelu, Y Zhang… - Journal of molecular …, 2013 - Elsevier
The C-terminal domain of the Dnmt3a de novo DNA methyltransferase (Dnmt3a-C) forms a
complex with the C-terminal domain of Dnmt3L, which stimulates its catalytic activity. We …
complex with the C-terminal domain of Dnmt3L, which stimulates its catalytic activity. We …