Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Background Gastric cancer (GC) ranks fifth in global cancer incidence and third in cancer-
related mortality. The prognosis of GC patients was poor. Necroptosis is a type of regulated …

When surveying the current literature on COVID-19, the “cytokine storm” is considered to be
pathogenetically involved in its severe outcomes such as acute respiratory distress …

Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …

Inflammation and cell death processes positively control the organ homeostasis of an
organism. Receptor-interacting protein kinase 1 (RIPK1), a member of the RIPK family, is a …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …

Necroptosis is a caspase-independent modality of cell death that requires the activation of
the executioner MLKL. In the last ten years the field gained a substantial amount of evidence …