Tissue engineering is a multidisciplinary field that applies the principles of engineering and
life-sciences for regeneration of damaged tissues. Stem cells have attracted much interest in …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

There is no consensus in the stem cell field as to what constitutes the mature cardiac
myocyte. Thus, helping formalize a molecular signature for cardiac myocyte maturation …

Carbon nanotubes (CNTs) were aligned in gelatin methacryloyl (GelMA) hydrogels using
dielectrophoresis approach. Mouse embryoid bodies (EBs) were cultured in the microwells …

Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …

Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that
recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are the most promising
source of cardiomyocytes (CMs) for experimental and clinical applications, but their use is …

Various cues from the microenvironment in which cells live can regulate cellular functions. In
addition to biochemical cues, increasing evidence has demonstrated that mechanical cues …

Engineered cardiac tissues that can be directly produced from human induced pluripotent
stem cells (hiPSCs) in scalable, suspension culture systems are needed to meet the …

In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …