Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

The identification of CD4+ T cell epitopes is instrumental for the design of subunit vaccines
for broad protection against coronaviruses. Here, we demonstrate in COVID-19–recovered …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

Skin is our primary interface with the environment, and T cells are crucial for orchestrating
host immune responses against pathogenic microorganisms at this site. Effective skin …

Mechanisms for human memory T cell differentiation and maintenance have largely been
inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Aerobic glycolysis regulates T cell function. However, whether and how primary cancer
alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a …