CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a
novel binding partner for some members of the integrin family. The αIIbβ3, specifically …

CD154 (CD40 ligand, CD40L, gp139) is a co-stimulatory molecule of the tumour necrosis
factor (TNF) family. CD154 was originally discovered on T-cells, and was found to be …

CD154 (CD40 ligand) is a type II transmembrane protein that belongs to the tumor necrosis
factor superfamily. The soluble form of CD154 (sCD154), which results from the shedding of …

Inhibition of the co‐stimulatory ligand CD40L has shown beneficial effects in many
experimental models of autoimmune disease and inflammation. Here, we show that CD40L …

In addition to its classical receptor, CD40, it is now well established that CD154 also binds
αIIbβ3, α5β1, and αMβ2 integrins. Although these integrins are all members of the same …

In addition to the membrane-bound form, CD154 also exists as a soluble molecule
originating from an intracellular and membrane cleavage. We have previously shown that …

CD154 plays a major role in the pathogenesis of several autoimmune and inflammatory
diseases. In addition to CD40, soluble CD154 (sCD154) binds to other receptors namely …

Interaction of CD40 with CD154 leads to recruitment of both molecules into lipid rafts,
resulting in bi-directional cell activation. The precise mechanism by which CD154 is …

Background Semaphorins are important molecules in embryonic development and multiple
semaphorins have been identified as having key roles in immune regulation. To date, there …

In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the
endfeet that abut the blood vessels of the brain. The asymmetric distribution of this channel …