In this review we take a physiological perspective on the role of voltage‐gated potassium
channels in an identified neuron in the auditory brainstem. The large number of KCN genes …

Multisite phosphorylation is an important mechanism for fine‐tuned regulation of protein
function. Mathematical models developed over recent years have contributed to elucidation …

Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …

The transcriptional activity of p53 is regulated by a cascade of posttranslational
modifications. Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to …

Reversible phosphorylation on serine, threonine and tyrosine is the most widely studied
posttranslational modification of proteins,. The number of phosphorylated sites on a protein …

The cardiac Na+ channel Na V 1.5 current (I Na) is critical to cardiac excitability, and altered
I Na gating has been implicated in genetic and acquired arrhythmias. Ca 2+/calmodulin …

Scn2a encodes the voltage-gated sodium channel Na V 1.2, a main mediator of neuronal
action potential firing. The current paradigm suggests that Na V 1.2 gain-of-function variants …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

Chemical derivatisation of functional groups has proved popular since the beginning of
organic mass spectrometry as a means to enhance the stability and volatility of the analytes …