Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy
Ion channelopathy plays an important role in human epilepsy with a genetic cause and has
been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired …
been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired …
Endoplasmic Reticulum–Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells
RE Dixon, JS Trimmer - Annual review of physiology, 2023 - annualreviews.org
Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …
Bottom‐up and top‐down proteomic approaches for the identification, characterization, and quantification of the low molecular weight proteome with focus on short …
The recent discovery of alternative open reading frames creates a need for suitable
analytical approaches to verify their translation and to characterize the corresponding gene …
analytical approaches to verify their translation and to characterize the corresponding gene …
Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of …
Background Many international guidelines on the prevention of venous thromboembolism
recommend targeting heparin treatment at patients with stroke who have a high risk of …
recommend targeting heparin treatment at patients with stroke who have a high risk of …
ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Nav1. 7 and alters its gating properties
S Stamboulian, JS Choi, HS Ahn… - Journal of …, 2010 - Soc Neuroscience
Nav1. 7 sodium channels can amplify weak stimuli in neurons and act as threshold channels
for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines that are …
for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines that are …
Dual-functional Ti (IV)-IMAC material enables simultaneous enrichment and separation of diverse glycopeptides and phosphopeptides
Simultaneous enrichment and fractionation of diverse proteins/peptides possessing different
post-translational modifications (PTMs) from the same biological samples is highly desirable …
post-translational modifications (PTMs) from the same biological samples is highly desirable …
Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity
AV Zaytsev, JE Mick, E Maslennikov… - Molecular Biology of …, 2015 - Am Soc Cell Biol
Microtubule (MT) attachment to kinetochores is vitally important for cell division, but how
these interactions are controlled by phosphorylation is not well known. We used quantitative …
these interactions are controlled by phosphorylation is not well known. We used quantitative …
Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice
Fragile X syndrome (FXS) is a common inherited form of mental retardation that is caused, in
the vast majority of cases, by the transcriptional silencing of a single gene, fmr1. The …
the vast majority of cases, by the transcriptional silencing of a single gene, fmr1. The …
Phosphorylation of the voltage-gated potassium channel Kv2. 1 by AMP-activated protein kinase regulates membrane excitability
N Ikematsu, ML Dallas, FA Ross… - Proceedings of the …, 2011 - National Acad Sciences
Firing of action potentials in excitable cells accelerates ATP turnover. The voltage-gated
potassium channel Kv2. 1 regulates action potential frequency in central neurons, whereas …
potassium channel Kv2. 1 regulates action potential frequency in central neurons, whereas …
Deletion of the Kv2. 1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability
DJ Speca, G Ogata, D Mandikian… - Genes, Brain and …, 2014 - Wiley Online Library
The Kv2. 1 delayed rectifier potassium channel exhibits high‐level expression in both
principal and inhibitory neurons throughout the central nervous system, including prominent …
principal and inhibitory neurons throughout the central nervous system, including prominent …