Kv2. 1, the primary delayed rectifying potassium channel in neurons, is extensively
regulated by phosphorylation. Previous reports have described Kv2. 1 phosphorylation …

The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2. 1 and Kv2.
2, mediate the bulk of the neuronal delayed rectifier K+ current in many mammalian central …

Sudden unexplained death in epilepsy (SUDEP) is the most common cause of premature
mortality in epilepsy and was linked to mutations in ion channels; however, genes within the …

Stable isotope labeling by amino acids (SILAC) metabolically encodes cell populations for
protein quantification by mass spectrometry. SILAC was introduced in 2002 and the field of …

Background Focused ultrasound stimulation (FUS) has the potential to provide non-invasive
neuromodulation of deep brain regions with unparalleled spatial precision. However, the …

Cyclin-dependent kinase activation can prevent yeast cells from responding to mating
pheromone. Strickfaden et al.(2007) now show that this block arises from the multisite …

Pro-inflammatory cytokines contribute to the cachexia associated with pancreatic cancer and
stimulate the acute phase response which has been associated with shortened survival in …

The voltage-gated Na channel isoform 1.5 (NaV1. 5) is the pore forming α-subunit of the
voltage-gated cardiac Na channel, which is responsible for the initiation and propagation of …

Multisite phosphorylation of kinases can induce on-off or graded regulation of catalytic
activity; however, its influence on substrate specificity remains unclear. Here, we show that …

The endoplasmic reticulum (ER) and plasma membrane (PM) form junctions crucial to ion
and lipid signaling and homeostasis. The Kv2. 1 ion channel is localized at ER–PM …