Kv1 channels are concentrated at specific sites in the axonal membrane, where they
regulate neuronal excitability. Establishing these distributions requires regulated …

Stable isotope labeling by amino acids in cell culture (SILAC) is a powerful approach for
high-throughput quantitative proteomics. SILAC allows highly accurate protein quantitation …

Total mortality and sudden cardiac death is highly prevalent in patients with chronic kidney
disease (CKD). In CKD patients, the protein-bound uremic retention solute indoxyl sulfate …

We investigate how post-translational phosphorylation modifies the global conformation of a
protein by changing its free energy landscape using two test proteins, cystatin and NtrC. We …

Key points Kv3. 1 and Kv3. 3 subunits are highly expressed in the auditory brainstem, with
little or no mRNA for Kv3. 2 or Kv3. 4. Changes in Kv3 currents and action potential (AP) …

Cardiac voltage-gated Na+ (Nav) channels are key determinants of action potential
waveforms, refractoriness and propagation, and Nav1. 5 is the main Nav pore-forming (α) …

Voltage-gated K+ channels are key regulators of neuronal excitability. The Kv2. 1 voltage-
gated K+ channel is the major delayed rectifier K+ channel expressed in most central …

Kv1. 2 α-subunits are components of low-threshold, rapidly activating voltage-gated
potassium (Kv) channels in mammalian neurons. Expression and localization of Kv …

Kv4. 2, as the primary α-subunit of rapidly inactivating, A-type voltage-gated K+ (Kv)
channels expressed in hippocampal CA1 pyramidal dendrites, plays a critical role in …

Silent voltage-gated K+ (Kv) subunits interact with Kv2 subunits and primarily modulate the
voltage dependence of inactivation of these heterotetrameric channels. Both Kv2 and silent …