Streptococcus pneumoniae is a colonizer of human nasopharynx, but it is also an important
pathogen responsible for high morbidity, high mortality, numerous disabilities, and high …

Most fungi are capable of disseminating into the central nervous system (CNS) commonly
being observed in immunocompromised hosts. Microglia play a critical role in responding to …

We evaluated the intracellular and extracellular biological role of S100B protein with respect
to microglia. S100B, which belongs to the multigenic family of Ca2+‐binding proteins, is …

The pathogenesis of cerebral infection after Cryptococcus neoformans fungemia in outbred
mice was investigated. Confocal microscopy and cultures on ficoll-hypaque gradient …

Activation of murine microglial and macrophage cell lines with lipopolysaccharide (LPS) and
interferon‐γ (IFN‐γ) resulted in the induction of the inducible form of nitric oxide synthase …

Both interleukin (IL)-4-and IL-13-dependent Th2-mediated immune mechanisms exacerbate
murine Cryptococcus neoformans-induced bronchopulmonary disease. To study the roles of …

Cryptococcus neoformans is an opportunistic fungus that causes life-threatening
meningoencephalitis in 5-10% of patients with acquired immune deficiency syndrome …

Animal models of fungal infections are, and will remain, a key tool in the advancement of the
medical mycology. Many different types of animal models of fungal infection have been …

Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000
human deaths per annum. Colonization of the central nervous system (CNS) by C …

PTX3 is a prototypic long pentraxin consisting of a C terminal 203-amino acid pentraxin-like
domain coupled with an N-terminal 178-amino acid unrelated portion. PTX3 is induced by …