Importance Autism spectrum disorder (ASD), characterized by deficits in social
communication and the presence of restricted, repetitive behaviors or interests, is a …

Autism spectrum disorder (autism) is a neurodevelopmental delay that affects at least 1 in 44
children. Like many neurological disorder phenotypes, the diagnostic features are …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Genome engineering technologies provide an entry point into understanding and controlling
the function of genetic elements in health and disease. The discovery and development of …

Preclinical models of neurodevelopmental disorders typically use single inbred mouse
strains, which fail to capture the genetic diversity and symptom heterogeneity that is common …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

More than 100 single gene mutations and copy number variants convey risk for autism
spectrum disorder. To understand the extent to which each mutation contributes to the …

The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …